“In the case of the Delta variant, neutralizing antibodies have a decreased affinity for the spike protein, whereas facilitating antibodies display a strikingly increased affinity. Thus, ADE may be a concern for people receiving vaccines…”

For aggressive redistribution: ADE may not be occurring with the original Covid strain, but rather, ADE among the “fully vaccinated” is particular to the Delta variant. This would explain everything we have been seeing for the past six weeks, and now we have the science to prove it. Anyone who has taken the vaxx needs to be on an accelerated prevention protocol. Share these links, copy and paste the images to social media, do whatever you can to spread the word.

Abstract

“Antibody dependent enhancement (ADE) of infection is a safety concern for vaccine strategies. In a recent publication, Li et al. (Cell 184 :1-17, 2021) have reported that infection-enhancing antibodies directed against the N-terminal domain (NTD) of the SARS-CoV-2 spike protein facilitate virus infection in vitro, but not in vivo. However, this study was performed with the original Wuhan/D614G strain. Since the Covid-19 pandemic is now dominated with Delta variants, we analyzed the interaction of facilitating antibodies with the NTD of these variants. Using molecular modelling approaches, we show that enhancing antibodies have a higher affinity for Delta variants than for Wuhan/D614G NTDs. We show that enhancing antibodies reinforce the binding of the spike trimer to the host cell membrane by clamping the NTD to lipid raft microdomains. This stabilizing mechanism may facilitate the conformational change that induces the demasking of the receptor binding domain. As the NTD is also targeted by neutralizing antibodies, our data suggest that the balance between neutralizing and facilitating antibodies in vaccinated individuals is in favor of neutralization for the original Wuhan/D614G strain. However, in the case of the Delta variant, neutralizing antibodies have a decreased affinity for the spike protein, whereas facilitating antibodies display a strikingly increased affinity. Thus, ADE may be a concern for people receiving vaccines based on the original Wuhan strain spike sequence (either mRNA or viral vectors). Under these circumstances, second generation vaccines with spike protein formulations lacking structurally-conserved ADE-related epitopes should be considered.”

https://pubmed.ncbi.nlm.nih.gov/34384810/

“By clamping the NTD and the lipid raft, the antibody reinforces the attachment of the spike protein to the cell surface and thus facilitates the conformational change of the RBD which is the next step of the virus infection process2.

“Neutralizing antibodies directed against the NTD have also been detected in Covid-19 patients45. The 4A8 antibody is a major representant of such antibodies5. The epitope recognized by this antibody on the flat NTD surface is dramatically affected in the NTD of Delta variants1, suggesting a significant loss of activity in vaccinated people exposed to Delta variants. More generally, it can be reasonably assumed that the balance between neutralizing and facilitating antibodies may greatly differ according to the virus strain (Figure 2 ).”

“This notion of a dual NTD-raft recognition by an infection enhancing antibody may represent a new type of ADE that could be operative with other viruses. Incidentally, our data provide a mechanistic explanation of the FcR-independent enhancement of infection induced by the 1054 antibody1. The model we propose, which links for the first time lipid rafts to ADE of SARS-CoV-2, is in line with previous data showing that intact lipid rafts are required for ADE of dengue virus infection3.”

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8351274/#!po=4.16667

“Current Covid-19 vaccines (either mRNA or viral vectors) are based on the original Wuhan spike sequence. Inasmuch as neutralizing antibodies overwhelm facilitating antibodies, ADE is not a concern. However, the emergence of SARS-CoV-2 variants may tip the scales in favor of infection enhancement. Our structural and modelling data suggest that it might be indeed the case for Delta variants.”

“In conclusion, ADE may occur in people receiving vaccines based on the original Wuhan strain spike sequence (either mRNA or viral vectors) and then exposed to a Delta variant…”

4 thoughts on ““In the case of the Delta variant, neutralizing antibodies have a decreased affinity for the spike protein, whereas facilitating antibodies display a strikingly increased affinity. Thus, ADE may be a concern for people receiving vaccines…”

  1. Canada to mandate COVID-19 jabs for domestic travel as well as for all federal workers

    The Canadian federal government under Liberal Party Prime Minister Justin Trudeau announced Friday that starting in October Canada will be mandating COVID-19 jabs as a requirement to travel domestically by air, train, or boat.

    “As soon as possible in the fall and no later than the end of October, the government of Canada will require employees in the federally regulated air, rail and marine transportation sectors to be vaccinated. In addition the vaccination requirement will also extend to certain travelers. This includes all commercial air travelers, passengers on interprovincial trains and passengers on large marine vessels with overnight accommodations such as cruise ships,” Canada’s Transport Minister Omar Alghabra said Friday.

    Alghabra said in addition to mandating COVID-19 jabs for domestic travel for Canadians, all federal workers will be required to be jabbed by October as well.

    “Today, we are announcing that the government of Canada intends to require vaccinations across the federal public service. Following this example, we also expect that crown corporations and other employers in the federally regulated sector will also require vaccination for their employees,” said Alghabra.

    https://www.lifesitenews.com/news/canada-to-mandate-covid-19-jabs-for-domestic-travel-as-well-as-for-all-federal-workers/

    This means that the Mark of the Beast must have a system in place for Canada by September.

    They are not going to stop at domestic travel and federal employees folks!

  2. “Accelerated Prevention Protocol”. What is that?!
    There are people I know who were obedient and naive and got both jabs. What is involved in the protocol.. Recall that we can’t necessarily rely upon the medical bureaucracy.

    1. For those who’ve already taken the jab it’s gonna be a lot different though….from all I’ve read damage is irreversable. Some are touting some mitigation of spike protein effect with dandelion extract (tincture or tea) and a special and specific type of pine needle tea (containing shikimic acid and suramin). But at the base, this is a real ‘mark’, both physical and spiritual, with delitrious ramifications for both modes. If it isn’t the actual mark of the beast, it’s intimately connected with it.

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