“In 28 days of follow-up, significant protection of ivermectin preventing the infection from SARS-CoV-2 was observed”

Jose Morgenstern 1Jose N Redondo 2Alvaro Olavarria 3Isis Rondon 4Santiago Roca 5Albida De Leon 6Juan Canela 7Johnny Tavares 8Miguelina Minaya 9Oscar Lopez 10Ana Castillo 10Ana Placido 11Rafael Cruz 12Yudelka Merette 12Marlenin Toribio 13Juan Francisco 13

Free PMC article

Abstract

Background: Ivermectin is a drug that has been shown to be active against coronavirus disease 19 (COVID-19) in previous studies. Healthcare personnel are highly exposed to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Therefore, we decided to offer them ivermectin as a pre-exposure prophylaxis (PrEP) method.

Purpose: Primary outcome was to measure the number of healthcare workers with symptomatic SARS-CoV-2 infection and a positive reverse transcription polymerase chain reaction (RT-PCR) COVID-19 test in the ivermectin group and in the control group. Secondary outcome was to measure the number of sick healthcare workers with a positive RT-PCR COVID-19 test whose condition deteriorated and required hospitalization and/or an Intensive Care Unit (ICU), or who died, in the ivermectin group and in the control group.

Material and methods: This observational and retrospective cohort study was carried out in two medical centers, Centro Medico Bournigal (CMBO) in Puerto Plata and Centro Medico Punta Cana (CMPC) in Punta Cana, Dominican Republic. The study began on June 29, 2020, and ended on July 26, 2020. A Statistical Package for Social Sciences (SPSS) Propensity Score Matching procedure was applied in a 1:1 ratio to homogeneously evaluate 271 healthcare personnel that adhered to a PrEP program with ivermectin at a weekly oral (PO) dose of 0.2 mg/kg, and 271 healthcare personnel who did not adhere to the program were assigned as a control group.

Results: In 28 days of follow-up, significant protection of ivermectin preventing the infection from SARS-CoV-2 was observed: 1.8% compared to those who did not take it (6.6%; p-value = 0.006), with a risk reduction of 74% (HR 0.26, 95% CI [0.10,0.71]). Conclusions: These results suggest that compassionate use of weekly ivermectin could be an option as a preventive method in healthcare workers and as an adjunct to immunizations, while further well-designed randomized controlled trials are developed to facilitate scientific consensus.

4 thoughts on ““In 28 days of follow-up, significant protection of ivermectin preventing the infection from SARS-CoV-2 was observed”

  1. If this pandemic were as bad as they’re saying, not only would things like Ivermectin (along with Vitamin C, D and Zinc and other things) be given a fair shot to save as many lives as possible, but also simple things like all the face masks, especially in hospitals, would all be in biohazard containers to be incinerated (also, all the retail workers of the nation would all be in mass-graves today, there is zero “social distancing” in Walmart, Target, Costco or any other big-box store you can name).

    Watch the old movie, “The Stand” where an influenza virus kills off almost all humans. There’s a scene where one of the characters who is immune is in a containment cell, and he pretends to get sick, and the evil doctor is terrified. THAT is how people should be reacting to a sickness during a real pandemic.

  2. “Pay no attention to that study behind the firewall. Look! Over there! Two double-jabbed squirrels. Glad to have their lives back. Grateful to science. Shunning misinformation. Getting a little bit out of breath when climbing up a tree now but sure it’s nothing to worry about.”

  3. https://c19early.com has data on 28 prophylactic and early treatment options, ranked by effectiveness in specific situations, with approximate costs and linked medical papers as references.

    The site is an ongoing meta-analysis study of numerous papers including the paper you quote here and is updated frequently as new papers are published, corrections received etc.

    There are separate pages for each of the 28 treatments considered, including https://c19ivermectin.com and https:ivmmeta.com

    The only unreliable part of the site is the boilerplate text about the jabs, but that may well be required just to “play the game” and keep the site from attacks.

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